Technology – Exero Medical

The xBar System

Actionable insights based on post-operative tissue healing data

Sensors

Electrode sensors are placed near the anastomosis site during surgery. The current xBar system has electrode sensors embedded in a standard surgical drain. The drain is placed and removed according to standard of care, with no change to the normal surgical procedure.

Tissue Healing Data

The electrodes are connected to a small device outside the patient’s body that records and relays data. The data is processed through Exero’s algorithm to assess tissue healing status and indicate risk of complications arising.

Clinician App

Data is provided to clinicians to support decisions around patient care.

Clinical Evidence

A pivotal study of the xBar technology is underway.

Pilot Study

100% sensitivity and 100% specificity in detecting severe leaks at post-operative day 3

A multi-center pilot study of 50 anterior resection patients monitored with the xBar system post-operatively demonstrated leak detection with 100% sensitivity and 91.5% specificity at POD 2, and 100% sensitivity and 100% specificity at POD 3. In all instances, severe leaks were detected at least 2 days earlier by xBar compared to the clinical team.

This study demonstrates clinical feasibility of the xBar system. Read more about the study here.

A pivotal study to validate the safety and accuracy of the xBar system for early detection of major complications such as severe leaks is ongoing at eleven sites across the United States and Israel.

Motility markers indicate local hypoxia.

Motility markers are disrupted in hypoxic and ischemic conditions typical to a leak.

Scientific Publications

June 4, 2024

Post-operative monitoring of intestinal motility, ischemia, and inflammation for early detection of anastomotic leaks

The objective of this multi-center pilot study was to evaluate if this device can reliably detect anastomotic leaks earlier than the current standard of care.

June 1, 2022

Implantation of an Impedance Sensor for Early Detection of Gastrointestinal Anastomotic Leaks

Accurate early diagnosis of a gastrointestinal anastomotic leak remains a challenge. When an anastomotic leak develops, the electrical properties of the tissue undergoing inflammatory processes change, resulting from the extravasation of inflammatory fluid and cellular infiltration.

August 31, 2021

DEGRADABLE BIOSENSOR FOR THE EARLY DETECTION OF ABDOMINAL SEPSIS

Introduction: Postoperative abdominal sepsis is often a catastrophic event with huge clinical, organizational and economic impact.

May 5, 2020

Colonic Tissue Perfusion Assessment Using Local Electrophysiological Sensing

Verification of adequate perfusion is essential to ensure anastomosis integrity following colonic resections. Perfusion monitoring intra and postoperatively is challenging, and existing methods are unable to provide reliable perfusion metrics over time.